INTERCONNECTION OF SUBSTANTIVE AND PROCEDURAL SIGNIFICANCE OF MOTIVE AND PURPOSE OF CRIME


Potent preclinical activity of FLT3-directed chimeric antigen receptor T-cell immunotherapy against FLT3- mutant acute myeloid leukemia and KMT2A-rearranged acute lymphoblastic leukemia

Chimeric antigen receptor (CAR) T-cell immunotherapies targeting CD19 or CD22 induce remissions in the majority of patients with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL), although relapse due to target antigen loss or downregulation has emerged as a major clinical dilemma.Accordingly, great interest exists in developing CAR T c

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Symplectic Maps from Cluster Algebras

We consider nonlinear recurrences generated from the iteration of maps that arise from cluster algebras.More precisely, starting from a skew-symmetric integer matrix, or its corresponding quiver, one can define a set of mutation operations, as well as a set of associated cluster mutations that are applied to a set of affine coordinates (the cluster

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Planning priority conservation areas under climate change for six plant species with extremely small populations in China

The concept of Plant Species with Extremely Small Populations (PSESP) has been employed to guide conservation of threatened plant species in China.Climate change has a high potential to threaten PSESP.As a result, it is necessary to Cherry integrate climate change effects on PSESP into conservation planning in China.Here, ecological niche modelling

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Identification and Characterization of Non-Saccharomyces Species Isolated from Port Wine Spontaneous Fermentations

In winemaking, non-Saccharomyces yeast species contribute important organoleptic complexity.Current interest focuses on abundant and dominant strains characteristically present in the early phase of spontaneous alcoholic fermentations.Non-Saccharomyces species are particularly relevant in Port wine production such that the fermentation is premature

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